近日，广东工业大学环境健康与污染控制研究院、环境科学与工程学院安太成教授团队，在我院自主创办的环境领域英文学术期刊Global Environmental Science上发表题为“Advancing Health Risk Assessment: Integrating Exposure Routes and Bioavailability to Quantify Internal Dose”的展望论文(Perspective)。论文的第一作者为博士生张芸芸，主要作者李桂英教授和顾建文教授，通讯作者为我院院长安太成教授。该论文聚焦当前健康风险评估模型的关键挑战，即受限于对暴露途径的简化处理，导致对毒害污染物的生物有效性内暴露剂量的定量不够准确，以暴露途径为主要关注视角，提出通过系统整合多途径暴露、引入基于人群异质性的概率性参数，并结合生物利用度校正，可显著提升有效内暴露剂量的估算精度，从而增强健康风险评估的科学性与可靠性。

 

环境作为人类健康的关键外部决定因素，其污染问题已构成严峻的全球公共卫生负担。然而，环境污染转化为实际健康风险的必要前提是人体暴露，即污染物必须通过特定暴露途径(摄入、吸入或皮肤接触)抵达人体受体部位。暴露途径作为环境污染转化为生物有效内暴露剂量的关键桥梁，直接调控污染物的生物利用度、组织分布和代谢活化等过程，共同塑造污染物生物有效的内暴露剂量，从根本上决定健康风险特征。从暴露途径的视角出发，现行风险评估模型存在以下四重缺陷：多种暴露途径割裂化评估、人群异质性简化、生物利用度校正缺失和特殊暴露途径的忽视。基于此，本文提出健康风险评估模型的发展建议，包括以下几条：整合多种暴露途径的暴露特征、采用概率模型反映人群异质性、利用生物利用度校正有效剂量，进而推动风险评估从“外暴露浓度”迈向“生物有效内剂量”精准量化暴露，以进一步提高毒害污染物的评估准确性和管理策略的有效性。

网址: https://doi.org/10.53941/ges.2025.100013

图文摘要：

英文题目：Advancing Health Risk Assessment: Integrating Exposure Routes and Bioavailability to Quantify Internal Dose

英文摘要：As the linkage between environmental pollution and health outcomes, exposure routes characterize how pollutants enter the human body, constituting the foundation of health risk assessment. Pollutants primarily enter body through three major routes: ingestion, inhalation, and dermal contact. The exposure routes govern the internal dose, tissue distribution, and metabolic fate of various environmental pollutants, fundamentally shaping the nature and magnitude of associate health risks. From the perspective of exposure routes, current risk assessment models exist several limitations, including the lack of systematic integration across multiple exposure routes; reliance on fixed default exposure parameters that fail to reflect population heterogeneity; dependence on external exposure dose such as daily intake, without accounting for bioavailability; and omission of special exposure routes. Therefore, modern health risk assessment frameworks must evolve to incorporate: integrated multi-route exposure assessments, probabilistic parameter distributions, and bioavailability-corrected effective dose. Only through such comprehensive improvements can achieve accurate characterization of exposure risks and provide a robust scientific basis for precision prevention and control.

项目资助：本研究受到国家重点研发计划（2023YFC3708204和2024YFC3713201）和广东省“珠江人才计划”引进创新与研究团队项目（2023ZT10L102）的联合资助。